Fibrino Gens

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human Fibrinogen (4F7) Antibody, Cy7 Conjugated

General information

Catalog number
bsm-1240M-Cy7
Name
human Fibrinogen (4F7) Antibody, Cy7 Conjugated
Price
350.00 EUR
Size
0.1ml

Detailed information

Long name
human Fibrinogen (4F7) Monoclonal Antibody, Cy7 Conjugated
Category
Conjugated Primary Antibodies
Conjugation
Cy7
Host Organism
Mouse (Mus musculus)
Target Antigen
human Fibrinogen
Specificity
This is a highly specific antibody against human Fibrinogen.
Modification
Unmodified
Modification site
None
Clonality
Monoclonal
Clone
4F7
Concentration
1ug per 1ul
Source
Fibrinogen from human plasma
Gene ID number
2243
Tested applications
IF(IHC-P)
Recommended dilutions
IF(IHC-P)(1:50-200)
Crossreactivity
Human
Crossreactive species details
Due to limited amount of testing and knowledge, not every possible cross-reactivity is known.
Antigen background
Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel A. et al, and Rapold H.J. et al). All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases.
Purification method
Purified by Protein G.
Storage conditions
Keep the antibody in an aqueous buffered solution containing 1% BSA, 50% glycerol and 0.09% sodium azide. Store refrigerated at 2 to 8 degrees Celcius for up to 1 year.
Excitation Emission
743nm/767nm
Synonyms
FGA; FGA protein; FGB; FGG; Fib2; Fibrin alpha chain ;Fibrinogen A alpha polypeptide; Fibrinogen A alpha polypeptide chain; Fibrinogen alpha chain; Fibrinogen B alpha polypeptide; Fibrinogen beta chain; Fibrinogen G alpha polypeptide; Fibrinogen gamma chain; MGC104327; MGC119422; MGC119423; MGC119425; MGC120405; FIBA_HUMAN.
Properties
If you buy Antibodies supplied by Bioss Primary Conjugated Antibodies they should be stored frozen at - 24°C for long term storage and for short term at + 5°C.Human proteins, cDNA and human recombinants are used in human reactive ELISA kits and to produce anti-human mono and polyclonal antibodies. Modern humans (Homo sapiens, primarily ssp. Homo sapiens sapiens). Depending on the epitopes used human ELISA kits can be cross reactive to many other species. Mainly analyzed are human serum, plasma, urine, saliva, human cell culture supernatants and biological samples.
Conjugated
These antibodies are excite for emission at 650 nm and detected at a 676 nm wavelengths.
Additional conjugation
Cy7
French translation
anticorps